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Fall 2006         Organic and Biological Chemistry, Chem 215              Lycoming College

Course description - This course is designed to introduce the student to the chemistry of organic compounds and survey various classes of biomolecules with regard to their structure and biological activity.  The laboratory component of this course is designed to reinforce topics discussed in the lecture as well as examine some basic techniques of the two disciplines.

Faculty
Dr. Chriss McDonald lectures, lab, recitations office HBC 233
*321-4186 (work), or e-mail (mcdonald@lycoming.edu)

Texts etc.
a. General, Organic and Biological Chemistry  by McMurry and Castelion, 4th Ed^#
b. Chemistry 215 Lab Manual, by McDonald^#
c. Bound laboratory notebook by Freeman^#
d. Lab safety glasses^
e. Calculator (add, subtract, multiply, divide, logs)^&

^#available at the bookstore

^sold by Chemistry Club

^& Please note that programmable calculators may not be used on quizzes and tests.

 

Course format
Lectures - MWF, 10:15 - 11:05, G-41, Attendance required.

Recitations - Tuesday, 1:00 – 1:50 PM, HBC 215.  The primary method for evaluating chemistry students in testing situations is to have them work problems.  In recitation we will practice the same sort of problems you will see in testing situations.  Attendance expected.  I will not take attendance but I might use some of the examples discussed in recitation as exam and quiz questions.  I have found that on the average, students who attend recitation in my courses get an average of one full letter grade higher than those who don’t attend.

Assigned homework - Problems designed to enhance your understanding and prepare you for testing situations.  A key will be posted outside the lab.  Homework will not be collected.  A large chunk of recitation will be devoted to working these problems.

Laboratory - T, 2:00 – 4:50 pm Tuesday, HBC 215, 239.  Attendance required.  Here you will experience what chemists actually do.  Your labwork will be evaluated as described in the lab syllabus as well as on the lecture exams.  Approximately 5% of each exam will be drawn from the labwork.  A lab syllabus will be distributed at the first lab session.  Make sure and show up with your $10 lab deposit (cash only) that first week.

Grading scheme
a. The final grade is based on the number of points obtained out of a possible 610 points.  The points will be distributed as follows:
 

quizzes	70 points (11%)
hour exams	300 points (49%)
final exam (cumulative)	100 points (16%)
laboratory	140 points (23%)
total	610 points

note:  If you score higher on the cumulative final exam this score will also be used to replace your lowest hourly exam score.

b. Assignment of letter grades is based on the following scale:  549 - 610 A, 488 - 548 B,  427 - 487 C, 366 - 426 D, < 366 F.

c. A word about learning chemistry.  Studying chemistry is hard work for most people  (this is certainly true for me).  I would recommend that you work on the lecture  material one hour per day outside of class for starters.  Once you see how things are going this amount can be adjusted as needed (I suggest a significant increase in study time prior to an exam).  If you are having trouble, make sure and come and see me.  I’m easy to talk to and will do whatever I can to help you. You will be responsible for all of the material listed on the following schedule for the indicated exams and quizzes.  It is not sufficient to learn the material from the lecture alone.  You are expected to read and think about the material prior to the lecture.  We must necessarily cover a large amount of material so our pace must be geared towards those who are ready to learn.  A major key to success is consistency of effort.  The hour exams will be somewhat cumulative in the sense that we need to know the earlier material to comprehend the latter.  For an idea of what my exams are like in Chem 215 see Appendix E in the Lab Manual.

Policy on attendance
Attendance at quizzes and exams is mandatory.  Makeups will not be administered.  If I deem the reason for absence to be legitimate and I am made aware of the absence beforehand, I will average subsequent quizzes or tests to account for the absence.  Each documented, unexcused lecture absence beyond the first two will cost you one point from your total.
 

 

 

 

 

 

Schedule 21506

date	topic	text	quiz/exam
8/28 M	introduction	1.1, 12.1	-
8/30 W	bonding, hydrocarbon structure	12.1,3,4,5	-
9/1 F	alkane and cycloalkane nomenclature	12.6,9,10, handout	-
9/4 M	alkane physical and chemical properties	12.7,8, 8.11	-
9/6 W	functional groups and Lewis structures	12.2, 5.5,6 handout	QUIZ 1
9/8 F	acid/base reactions and how they occur	10.1-6, handouts	-
9/11 M	alkene nomenclature	13.1,2,3	-
9/13 W	alkene addition reactions/ mechanism	13.5,6,7	QUIZ 2
9/15 F	as above	13.5,6,7	-
9/18 M	as above	13.5,6,7	-
9/20 W	arene substitution reactions	13.9,11	QUIZ 3
9/22 F	alcohol nomenclature and physical props	14.1-4, 8.11	-
9/25 M	alcohol oxidation reactions	14.5, 6.12,13	-
9/27 W	EXAM 1	-	EXAM 1
9/29 F	thiols	14.9	-
10/2 M	aldehyde/ketone nomenclature	16.1-3, 8.11	-
10/4 W	A/K redox	16.5,6	-
10/6 F	reaction of A/K  with alcohols	16.7	-
10/9 M	carboxylic acid nomenclature/acidity	17.1-3	-
10/11 W	esterification	17.4	QUIZ 4
10/13 F	nomenclature/properties of esters	17.1	-
10/16 M	Amines and amides	15.1-5, 17.4
10/18 W	EXAM 2	-	EXAM 2
10/20 F	applications of amine and amide chemistry	17.7	-
10/23 M	enantiomers	handout, 18.5,6	-
10/25 W	plane-polarized light and optical rotation	handout, 18.5,6
10/27 F	long weekend
10/30 M	diastereomers	handout	-
11/1 W	resolution	-	QUIZ 5
11/3 F	monosaccharides	18.1, 22.1-6	-
11/6 M	disaccharides	22.7	-
11/8 W	polysaccharides	22.9	QUIZ 6
11/10 F	amino acid structure	18.2,3,5
11/13 M	pH, pKa, and pI of a.a's	18.4	-
11/15 W	EXAM 3	-	EXAM 3
11/17 F	protein structure	18.7-11	-
11/20 M	protein structure	18.12
11/22 W	Tgiving	-
11/24 F	Tgiving		-
11/27 M	enzyme intro	19.1-3	-
11/29 W	how enzymes work	19.4-8	QUIZ 7
12/1 F	nucleic acid structure	26.1-4	-
12/4 M	replication, transcription	26.6-8	-
12/6 W	translation	26.9-10	-
12/8 F	review	-	-
12/11 through 12/15	FINAL EXAMINATIONS	-	-

 
 
 
 
 
 
 
 

 

 

 

 

 

Chem 21505  Lab Schedule

week	date	experiment(s)	read chp.
1	8/29	Check in/introduction	1,2
2	9/5	Simple and Fractional Distillation of a Mixture	3,5
3	9/12	Reaction of 2-Methyl-1-propanol with Propanoic Acid (7A) (Distillation  writeup due)	7
4	9/19	Distillation of rum flavoring  (7B)	4,7
5	10/3	Qualitative Organic Analysis (Rum flavoring lab writeup due)	9
6	10/10	Synthesis of Benzil (13A) (Qualitative Org. Anal. writeup due)	13
7	10/17	recrystallization of benzil (13B),  The Synthesis of Dilantin (13A)	11-14
8	10/24	characterization of benzil (13C), recrystallization of Dilantin (14B) (Benzil lab due)	13, 14
9	10/31	The Isolation of (+) - Limonene from    Orange Peel (Chp. 14, part 1), characterization of dilantin (14C)	14, 15
10	11/2	Separation of Acidic and Neutral Substances by Extraction (10A), polarimetry of limonene (Chp. 14, part 2) (Dilantin writeup due)	9,15
11	11/9	Isolation/characerization of acidic and neutral substances, (Limonene writeup due)	15
12	11/16	Characterization of Carbohydrates (16)	16
13	11/29	Comparison of E. Coli Membrane Fatty Acid Composition at Two Different Temperatures (Carbohydrate writeup due)	19
14	12/5	GCMS shoots and Checkout(!)	19
-	12/8	Comparison of e. coli writeup due	-

 
GRADING:  The lab component of  your grade is 140 points out of the 610 for the course.  There will be 9 grades for writeups (14 points each).  Makeups for missed labs are often not possible.  A typical grade for a writeup  can be broken down into three parts:  content of the writeup (60%), yield of the product (20%), purity of the product (20%).  Late lab writeups will cost you 5% per school day.  The remaining 14 points of the lab grade will be based on an assessment done by the instructor and TA of your performance in the lab.  Three areas will be evaluated:  1.  preparation - have you read the lab and do you have a fair idea of what should transpire?  2. lab etiquette - do you clean up after yourself (including the common areas of the lab such as balances, melting point apparati...) and treat your labmates with respect?; 3. safety - are safety rules followed?

 

USEFUL SUPPLEMENTARY SOURCES:  One part of your  lab writeup requires you to list several physical properties for the compounds involved in that particular experiment.  This information can be obtained most conveniently from one of the following:
1) The Merck Index - located in the lab, the reading room, and the library reference collection (RS.51);
2) The CRC Handbook of Chemistry and Physics - located in the lab, the reading room, and the library reference collection (QD.65);

3) The Aldrich Catalog - located in the lab and the reading room;
4) Chemfinder.com

 

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